The TenDRA Project
The source tree is organised into several independent programs. These are intended to be packaged separately, and may be built independently of each other. See the Orientation Guide  for details of how this all fits together.
The top-level Makefile provided here is a convenience to build everything. If you just want to try TenDRA out, this is what you're looking for.
This can be any BSD's native make(1). An ancient version of NetBSD's make is sometimes packaged as "pmake". There's also sjg's portable bmake, which you can get here: http://www.crufty.net/help/sjg/bmake.html
GNU's gmake uses a completely different syntax, and is not supported.
See shared/mk/tendra.compiler.mk for supported compilers.
This should be no problem for any of the supported OSes; their provided toolchains will do fine. For Linux and BSDs this is GNU's ld, as, etc.
This is trickier than it sounds. I've been working to make it easier, and it's certainly easier than it was, but there's still some way to go before you can expect a build to work on an arbitrary platform.
In particular there is currently no code generation for 64-bit platforms (other than Alpha) - so no x86_64, mips64, UltraSPARC, 64-bit PA-RISC etc.
You can see the supported architectures under /trans/src.
TenDRA needs to know not only what the OS is, but also what version.
You can see supported OSes under /osdep/machines.
This where it gets more difficult. The particular version of your libc matters due to the version-specific workarounds for various non-standard or incorrect things in your system headers.
You can see the supported libc implementations under /api/libc.
If your particular libc is not supported, it's straightforward to add. However this is something of a dark art, involving figuring out where system headers deviate from the various standards TenDRA enforces (ANSI, POSIX and so on), and what to do about it which is decided case-by-case.
I've started writing a guide on how to do this. 
I'd suggest using either OpenBSD, FreeBSD or Linux. If you're using Linux, install pmake.
Look at /shared/mk/tendra.makedefs.mk for some idea of supported versions, pick one, and try it. Talk to me if it doesn't work. 
% bmake -r
If all goes well, this should give you a working compiler in ./obj.$host-bootstrap/bin
The Dockerfile defines a base system that can compile the compiler. You will need to build the docker image first, but thereafter you can just run it (without the --build parameter).
To build and run the docker image: % ./run-docker.sh --build
There is currently no code generation for x8664 assembly. So you can't produce native x8664 executables. However, for systems with multilib support (FreeBSD, Linux), you can build TenDRA such that it will generate x8632 executables on an x8664 system:
% make TARGETARCH=x32_64 % ./obj.iona-bootstrap/bin/tcc hello.c
which gives you this:
% ./a.out hello, world % uname -sm Linux x86_64 % file a.out a.out: ELF 32-bit LSB executable, Intel 80386, version 1 (SYSV), dynamically linked (uses shared libs), ... %
When building for x3264, you'll need x8632-compatible libc headers. For Debian, that's packaged as libc6-dev-i386.
 Orientation Guide: /tendra-doc/doc/developer/guides/orientation
 Porting TenDRA to Different Operating Systems: /osdep/doc/devguides/porting
 IRC: #tendra on irc.freenode.net