A Hidden Markov Model Application and C++ Library for Rapid and Flexible Development of HMMs
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StochHMM is a free, open source C++ Library and application that implements HMM from simple text files. It implements traditional HMM algorithms in addition it providing additional flexibility. The additional flexibility is achieved by allowing researchers to integrate additional data sources and application into the HMM framework.
For documentation on model syntax and designing a model, see Github wiki.
Here are a few of the ways that StochHMM allows the users to integrate additional data sources: 1. Multiple Emission States 2. Weighting or Explicitly Defining State paths on a sequence 3. Linking States Emissions/Transitions to external user-defined functions
StochHMM allows the user to provide multiple sequences. These sequences are then handled by the emissions. These sequences can be REAL numbers or discrete characters/words. StochHMM allows each state to have many emissions (Discrete or Continuous). Discrete emissions can be independent of each other or joint distributions. The continuous emissions can be considered in multiple ways. 1) They can be considered as raw probabilities which will be integrated without transformation. 2) They can be considered as values to be plugged into a Univariate Probability Distribution Function or Multivariate PDF (In the case of multiple REAL sequences.
Each states emissions are user-defined, so one state may have emissions from two different sequences, while another may only have a single emission from a single sequence.
Often, we have some prior knowledge about the sequence. If this is the case, we may want to integrate that into the model, without redesigning or retraining the model (a timely endeavor). StochHMM allows the user to explicitly define a State path (By name of state, or category of state). In addition, StochHMM also allows the user to weight a states path (By name of State or category of state defined by user) This allows the user to restrict the predicted path or weight their prior knowledge.
When that transition/emission is evaluated the function is called and can provide an emission. While this may provide one way of addressing a weakness of HMMs, which is that they do not handle long range dependencies. We see it rather as a way to link together existing utilities or functions that provide additional information to the decoding algorithms. In this way, we can link divergent datasets or functions within the HMM trellis in order to arrive at a better prediction.
Documentation for the C++ code can be found at StochHMM Doxygen Documentation
Documentation on the Model files can be found at StochHMM Github Wiki
Schroeder, D.I., Blair J.D., Lott P., Yu H.O., Hong D., Crary F., Ashwood P., Walker C. , Korf I., Robinson W.P., LaSalle J.M.. The human placenta methylome. PNAS 15:6037-6042 (2013)
Lott, P., Dunaway, K., Yu, K., Korf, I. StochHMM: A Flexible Hidden Markov Model Framework for Rapid Development of HMMs. Poster presented at: Genome Informatics, 2012 Sep 6-9, Cambridge, UK.
Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I. & Chédin, F. R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol. Cell 45, 814–825 (2012).
Schroeder, D. I., Lott, P., Korf, I. & LaSalle, J. M. Large-scale methylation domains mark a functional subset of neuronally expressed genes. Genome Res 21, 1583–1591 (2011).
To compile StochHMM in Unix command-line (Linux, Mac OS X)
$ ./configure $ make
Compiled application ./stochhmm will be located in the projects root folder and the static library will be in the src/ folder.
To compile StochHMM in XCode (Mac OS X only)
Compiled target will be accessible from Xcode
To run the examples,
$ cd bin/ $ stochhmm -model ../examples/Dice.hmm -seq ../examples/Dice.fa -viterbi -label $ stochhmm -model ../examples/3_16Eddy.hmm -seq ../examples/3_16Eddy.fa -viterbi -gff $ stochhmm -model ../examples/3_16Eddy.hmm -seq ../examples/3_17Eddy.fa -posterior $ stochhmm -model ../examples/Dice.hmm -seq ../examples/Dice.fa -stochastic viterbi -rep 10 -label $ stochhmm -model ../examples/Dice.hmm -seq ../examples/Dice.fa -stochastic posterior -rep 10 -label
The MIT License (MIT)
Copyright (c) 2007-2012 Paul Lott, Ian Korf, Korf Lab, Genome Center, UC Davis, Davis, CA. All rights reserved.
Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:
The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.